HemeScreen Reagents

HemeScreen® Reagents Product Information

HemeScreen is a Research Use Only (RUO) proprietary mutation detection technology that is rapid, cost-effective, and easy-to-use. HemeScreen reagents can be run on most RT-PCR instruments and leverage efficient HRM (High Resolution Melt) technology to identify gene mutations and other variants at low limits of detection.

HemeScreen enables testing of multiple genes of interest (driver mutations) for these blood cancers on a single platform, in a pre-plated assay configuration to further simplify clinical hematopathology workflows.
Does HemeScreen® Make Sense For My Lab?


MPN Panel

JAK2 Exon 14 (V617F)
JAK2 Exon 12
CALR
JAK2 Exon 13
MPL

AML Panel

IDH1
IDH2
KIT
CEBPA
FLT3
NPM1

CLL Panel

MYD88
NOTCH1
CXCR4
SF3B1

Cytopenia Panel

ASXL1
DNMT3A
SF3B1
RUNX1
WT1

HemeScreen was developed in Precipio’s own clinical hematopathology laboratory to address the issues of turn-around time and accurate, comprehensive molecular testing for various blood cancers.

Typical HemeScreen® Workflow

DNA Workflow

The HemeScreen workflow simplifies comprehensive analyses of driver mutations for various hematopathology diseases such as myeloproliferative neoplasms (MPN), Cytopenia, Myelodysplastic syndromes (MDS), Acute myeloid leukemia (AML), Chronic lymphocytic leukemia (CLL), and Chronic myeloid leukemia (CML). Samples received are prepared using standard DNA extraction processes, followed by a simple plating step onto the pre-plated HemeScreen 96 well plates. These samples are the amplified and data is collected in real time, followed by simple melt curve analysis and interpretation for mutation detection.

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